Text or faces in the covered areas can’t be seen, no matter how good they are.
Keeping on-screen text in the upper-middle of the frame, clear of the right-side buttons.
Putting your hook text at the very bottom, where the caption covers it.
How to use it
Every app covers a slightly different area, and layouts change, so check before you export. The safest region is roughly the middle of the frame, away from the bottom edge and the right side. If you post the same video to several apps, use the area that’s safe on all of them.